 Margaret J. Wortman,
Ph.D.
Research Assistant Professor
Lewis Hall, #3144
Office: (757) 446-5953
Email: wortmamj@evms.edu
Biomedical Sciences
Program Track:
Molecular Integrative
Biosciences (MIB)
Education
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B.A., MacMurray College,
Jacksonville, IL
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M.S., University of
Florida, Gainesville, FL
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Ph.D., New York University,
New York, NY
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Postdoctoral Training, The
Rockefeller University and Mount Sinai School of
Medicine, New York, NY
Selected Publications
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Wortman, M.J.,
Johnson, E.M., and Bergemann, A.D. Mechanism of DNA
binding and localized strand separation by Puralpha and
comparison with Pur family member, Purbeta, BBA Mol.
Cell Res. Accepted Aug. 20, 2004, Available online Sept.
27, 2004.
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Daniel, D.C.,
Wortman, M.J., Schiller, R.J., Liu, H., Gan,
L.. Mellen, J.S., Chang, C.F., Gallia, G.L., Rappaport,
J., Khalili, K., and Johnson, E.M. Coordinate effects of
human immunodeficiency virus type 1 protein Tat and
cellular protein Puralpha on DNA replication initiated
at the JC virus origin. J. Gen Virol. 2001. 82(Pt
7):1543-53.
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Wortman, M.J.,
Krachmarov, C.P., Kim, J.H., Gordon, R.G., Chepenik, L.G.,
Brady, J.N., Gallia, G.L., Khalili, K., and Johnson, E.M.
Interaction of HIV-1 Tat with Puralpha in nuclei of
human glial cells: characterization of RNA-mediated
protein-protein binding. J. Cell Biochem.
2000.77(1):65-74.
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Gallia, G.L., Darbinian,
N., Tretiakova, A., Ansari, S.A., Rappaport, J., Brady,
J., Wortman, M.J., Johnson, E.M., and
Khalili, K. Association of HIV-1 Tat with the cellular
protein, Puralpha, is mediated by RNA. Proc. Natl. Acad.
Sci. USA. 1999. 96(20):11572-7.
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Itoh, H., Wortman, M.J.,
Kanovsky, M., Uson, R.R., Gordon, R.E,, Alfano, N., and
Johnson, E.M. Alterations in Pur(alpha) levels and
intracellular localization in the CV-1 cell cycle. Cell
Growth Differ. 1998.9(8):651-65.
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Solomon, J.J., Cote, I., L,
Wortman, M., Decker, K., and Segal, A. In vitro
alkylation of calf thymus DNA by acrylonitrile.
Isolation of cyanoethyl-adducts of guanine and thymine
and carboxyethyl-adducts of adenine and cytosine. Chem
Biol Interact. 1984. 51(2):167-90.
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Wortman, M.J.,
and Segal, A. The isolation and purification of mouse
epidermal nuclei. Anal. Biochem. 1981. 115(1):147-50.
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Segal, A., Mate, U., and
Wortman, M.
Phosphate diester formation following reaction of beta-propiolactone
with thymidine-5'-monophosphoric acid. Chem. Biol.
Interact. 1978.21(2-3):249-61.
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