 Julius
O. Nyalwidhe, Ph.D.
Research Assistant Professor
Lewis Hall, #3011
Office: (757) 446-5682
nyalwijo@evms.edu
Biomedical Sciences
Program Track:
Molecular Integrative
Biosciences (MIB)
Education
- B.S., Kenyatta
University, Kenya
- M.S., University of
Nairobi, Kenya
- Ph.D., Philipps
University, Marburg, Germany
- Postdoctoral Training,
Philipps University, Marburg, Germany
Research Interests
Dr. Nyalwidhe is interested
in the application of functional, expressional and
structural proteomics approaches to the study of human
diseases with emphasis on infectious diseases and cancer.
This includes research on human malaria caused by Plasmodium
falciparum, a variety of other infectious agents, prostate
cancer and viral-induced carcinomas, in addition to other
forms of cancer.
The focus is on the
mechanisms of interaction between infectious pathogens and
their host cells, the mechanism of metastasis in cancer and
the analysis of the proteome of human body fluids to
identify clinically useful biomarkers for the diagnosis and
prognosis of disease. Dr. Nyalwidhe is also using molecular
biology and different mass spectrometry techniques in
analyzing, monitoring and quantifying post-translational
modifications in proteins to determine their influence in
the progression and outcome of disease.
Selected Publications
- Jones D, Nyalwidhe J,
Tetley L, Barret MP (2007). McArthur revisited: fluorescence
microscopes for field diagnostics. Trends Parasitol. 23:
468-9.
- Azim-Zadeh O, Hillebrecht
A, Linne U, Marahiel MA, Klebe G, Lingelbach K, and
Nyalwidhe J. (2007). Use of biotin derivatives to probe
conformational changes in proteins. J Biol Chem. 282: 21609
– 21617.
- Shamseldin A, Nyalwidhe J,
and Werner D. (2006). A proteomic approach towards the
analysis of salt tolerance in Rhizobium etli and
Sinorhizobium meliloti strains. Current Microbiology.
52:333-339.
- Nyalwidhe J, and
Lingelbach K (2006). Proteases and Chaperones are the most
abundant proteins in the parasitophorous vacuole of
Plasmodium falciparum – infected erythrocytes. Proteomics.
5:1563-73.
- Baumeister S, Endermann T,
Charpian S, Nyalwidhe J, Duranton C, Huber S, Kirk K, Lang
F, and Lingelbach K (2003). A biotin derivative blocks
parasite induced novel permeation pathways in Plasmodium
falciparum - infected erythrocytes. Mol Biochem Parasitol.
132:35-45.
- Nyalwidhe J, Maier U-G,
and Lingelbach K (2003).Intracellular parasitism: cell
biological adaptations of parasitic protozoa to a life
inside cells. Zoology 106: 341-48.
- Nyalwidhe J, Baumeister S,
Hibbs AR, Tawill S, Papakrivos J, Volker U, and Lingelbach K
(2002). A nonpermeant biotin derivative gains access to the
parasitophorous vacuole in Plasmodium falciparum-infected
erythrocytes permeabilized with streptolysin O.J Biol Chem.
277: 40005-11.
- Wiek S, Nyalwidhe J, and
Lingelbach K (2002).Verteilung von Parasitenproteinen in
infizierten Erythrozyten - Ein Schlüsselereignis bei der
Patho-genese der Malaria. Bioforum 10: 678-80.
- Khan B, Omar S, Kanyara JN,
Warren-Perry M, Nyalwidhe J, Peterson DS, Wellems T, Kaniaru
S, Gitonga J, Mulaa FJ, and Koech DK. (1997). Antifolate
drug resistance and point mutations in Plasmodium falciparum
in Kenya. Transactions of the Royal Society of Tropical
Medicine and Hygiene, 91, 456-460.
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