 Laura
K. Hanson, Ph.D.
Research Assistant Professor
Lewis Hall, #3148
Office: (757) 446-5664
hansonlk@evms.edu
Teaching: N/A
Biomedical Sciences Program Track: Cell Biology and
Molecular Pathogenesis
Basic Science Focal Research Group: Cancer Biology
and Virology
Education
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B.S., University of
Washington
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Ph.D., Cornell University
-
Postdoctoral Training,
Eastern Virginia Medical School
Research Interests
Dr. Hanson’s interest is in
the mechanisms of viral pathogenesis. Her studies focus on
murine cytomegalovirus (MCMV) as a model system to examine
genes important for ß- herpesvirus infection. Previously she
has identified two novel viral genes, named m142 and m143,
which are essential for replication of MCMV. These genes
belong to a gene family, found throughout the ß-
herpesviruses, whose functions are generally unknown. Using
a combination of molecular biological approaches with
traditional virological methods, she is examining both the
regulation of expression of these genes and the essential
function they perform for the virus.
Selected Publications
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Jones, T. R., Hanson, L.
K., Sun, L., Slater, J. S., Stenberg, R. S., and
Campbell, A. E. (1995). Multiple independent loci within
the human cytomegalovirus unique short region
down-regulate expression of major histocompatibility
complex class I heavy chain. J. Virol. 69: 4830-4841.
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Hanson, L. K.,
Dalton, B. L., Karabekian, Z., Farrell, H. E., Rawlinson,
W. D., Stenberg, R. M., and Campbell, A. E. (1999).
Transcriptional analysis of the murine cytomegalovirus
HindIII-I Region: Identification of a novel
immediate-early gene region. Virology. 260: 156-164.
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Hanson, L. K.,
Slater, J. S., Karabekian, Z., Virgin, H. W., Biron, C.
A., Ruzek, M. C., van Rooijen, N., Ciavarra, R. P.,
Stenberg, R. S., and Campbell, A. E. (1999). Replication
of murine cytomegalovirus in differentiated macrophages
as a determinant of viral pathogenesis. J. Virol. 73:
5970-5980.
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Hanson, L.K.,
Slater, J.S., Karabekian, Z., Ciocco-Schmitt, G., and
Campbell, A.E. (2001). Products of US22 genes M140 and
M141 confer efficient replication of murine
cytomegalovirus in macrophages and spleen. J. Virol. 75:
6292-6302.
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